Advanced Simulation Library (ASL) is a free and open source hardware accelerated multiphysics simulation platform (and an extensible general purpose tool for solving Partial Differential Equations). Its computational engine is written in OpenCL and utilizes matrix-free solution techniques which enable extraordinarily high performance, memory efficiency and deployability on a variety of massively parallel architectures, ranging from inexpensive FPGAs, DSPs and GPUs up to heterogeneous clusters and supercomputers. The engine is hidden entirely behind simple C++ classes, so that no OpenCL knowledge is required from application programmers. Mesh-free, immersed boundary approach allows to move from CAD directly to simulation drastically reducing pre-processing efforts and amount of potential errors. ASL can be used to model various coupled physical and chemical phenomena and employed in a multitude of fields: computational fluid dynamics, virtual sensing, industrial process data validation and reconciliation, image-guided surgery, computer-aided engineering, design space exploration, crystallography, etc..