The basics seem to work fine. I did find some problems related to handling RPMs and Flatpaks together, though:
They don't appear to be regressions, though, so a thumbs up.
The wifi crash no longer occurs. The remaining issue reported as: https://gitlab.gnome.org/GNOME/gnome-control-center/-/issues/2109
Since it seems FESCo will approve the change the prefer (any) Flatpaks over RPMs, I tested gnome-software again. It seems to be working mostly fine, but the Flatpak priority change doesn't work correctly for Featured apps. Reported here: https://gitlab.gnome.org/GNOME/gnome-software/-/issues/1946