On two F33 systems (one a MATE desktop and one a server), DNS resolution breaks when I boot this kernel. Watching tcpdump, no packets go on the wire when I attempt DNS lookups. Both systems have the default resolv.conf with systemd-resolved.
I just updated ca-certificates from F31 updates-testing without getting the p11-kit updates, and it broke certificate validation for all sites (including dnf trying to check the metalink). The ca-certificates update needs a requires on the newer version of p11-kit.